
4-Bromo-2-fluoro-N-methylbenzamide synthesis
- Product Name:4-Bromo-2-fluoro-N-methylbenzamide
- CAS Number:749927-69-3
- Molecular formula:C8H7BrFNO
- Molecular Weight:232.05

593-51-1
548 suppliers
$21.00/100g

112704-79-7
526 suppliers
$15.00/5 g

749927-69-3
288 suppliers
$40.00/1 g
Yield:749927-69-3 100%
Reaction Conditions:
with (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate;N-ethyl-N,N-diisopropylamine in dichloromethane at 20; for 2 h;
Steps:
Compound 49: (4-Bromo-2-fluoro-benzyl)-methyl-amine.
Compound 49: (4-Bromo-2-fluoro-benzyl)-methyl-amine. (1029) A mixture of 4-bromo-2-fluorobenzoic acid (1.0 equiv.), methylamine hydrochloride (1.1 equiv.), benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (1.1 equiv.) and diisopropylethylamine (3.3 equiv.) in dichloromethane (0.20 mol.L-1) was stirred for 2 hours at room temperature. The reaction mixture was hydrolyzed and extracted twice with dichloromethane. The organic layers were combined, washed with brine, dried over MgSO4, concentrated, and purified by flash column chromatography on silica gel (10% to 50% EtOAc in cyclohexane) to afford the intermediate methylamide as a white solid in quantitative yield.
References:
MAVALON THERAPEUTICS LIMITED;SCHANN, Stephan;MAYER, Stanislas;MANTEAU, Baptiste WO2017/81483, 2017, A1 Location in patent:Page/Page column 228-229

112704-79-7
526 suppliers
$15.00/5 g

74-89-5
7 suppliers
$13.44/25ML

749927-69-3
288 suppliers
$40.00/1 g

74-89-5
7 suppliers
$13.44/25ML

749927-69-3
288 suppliers
$40.00/1 g

151982-51-3
149 suppliers
$9.00/250mg

74-89-5
7 suppliers
$13.44/25ML

749927-69-3
288 suppliers
$40.00/1 g

112704-79-7
526 suppliers
$15.00/5 g

749927-69-3
288 suppliers
$40.00/1 g