1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene synthesis
- Product Name:1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene
- CAS Number:864725-22-4
- Molecular formula:C9H5Cl2F3
- Molecular Weight:241.04
2065-66-9
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130336-16-2
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Yield:864725-22-4 79%
Reaction Conditions:
with potassium tert-butylate in tetrahydrofuran at 20 - 25; for 1.5 h;Product distribution / selectivity;
Steps:
S.8
To a suspension of methyl-triphenylphosphonium bromide (16.17 g, 25.27 mmol) and 3,5-dichloro-2,2,2-trifluoro acetophenone (10.0 g, 41 .15 mmol) in THF (65 mL) was added KOtBu (5.54 g, 49.38 mmol) in THF (28 mL) at 20-25°C. After 1 .5 h at room temp, the reaction was complete by GC. The mixture was separated between n- heptane and water. The organic layer was separated, washed with brine and the solvent was removed in vacuum. After cooling, the mixture was filtered from precipitating triphenylphosphine oxide to yield the title compound (8.78 g, 79%).1H-NM R (360 M Hz, CDCI3): δ = 5.82 (s, 1 H), 6.06 (s, 1 H), 7.32 (s, 2H), 7.38 (s, 1 H) ppm.
References:
BASF SE;KÖRBER, Karsten;KORDES, Markus;RACK, Michael;VON DEYN, Wolfgang;KAISER, Florian WO2012/59441, 2012, A2 Location in patent:Page/Page column 51
1514-82-5
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67492-50-6
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864725-22-4
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1779-49-3
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130336-16-2
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1031-15-8
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130336-16-2
338 suppliers
$7.00/100mg
864725-22-4
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677-21-4
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67492-50-6
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