![](/CAS/20150408/GIF/864725-22-4.gif)
1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene synthesis
- Product Name:1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene
- CAS Number:864725-22-4
- Molecular formula:C9H5Cl2F3
- Molecular Weight:241.04
![Methyltriphenylphosphonium iodide](/CAS/GIF/2065-66-9.gif)
2065-66-9
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$5.00/5g
![3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE](/CAS/GIF/130336-16-2.gif)
130336-16-2
305 suppliers
$7.00/100mg
![1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene](/CAS/20150408/GIF/864725-22-4.gif)
864725-22-4
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Yield:864725-22-4 79%
Reaction Conditions:
with potassium tert-butylate in tetrahydrofuran at 20 - 25; for 1.5 h;Product distribution / selectivity;
Steps:
S.8
To a suspension of methyl-triphenylphosphonium bromide (16.17 g, 25.27 mmol) and 3,5-dichloro-2,2,2-trifluoro acetophenone (10.0 g, 41 .15 mmol) in THF (65 mL) was added KOtBu (5.54 g, 49.38 mmol) in THF (28 mL) at 20-25°C. After 1 .5 h at room temp, the reaction was complete by GC. The mixture was separated between n- heptane and water. The organic layer was separated, washed with brine and the solvent was removed in vacuum. After cooling, the mixture was filtered from precipitating triphenylphosphine oxide to yield the title compound (8.78 g, 79%).1H-NM R (360 M Hz, CDCI3): δ = 5.82 (s, 1 H), 6.06 (s, 1 H), 7.32 (s, 2H), 7.38 (s, 1 H) ppm.
References:
BASF SE;KÖRBER, Karsten;KORDES, Markus;RACK, Michael;VON DEYN, Wolfgang;KAISER, Florian WO2012/59441, 2012, A2 Location in patent:Page/Page column 51
![2-BROMO-3,3,3-TRIFLUOROPROPENE](/CAS/GIF/1514-82-5.gif)
1514-82-5
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$45.00/5 g
![3,5-Dichlorophenylboronic acid](/CAS/GIF/67492-50-6.gif)
67492-50-6
333 suppliers
$6.00/1g
![1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene](/CAS/20150408/GIF/864725-22-4.gif)
864725-22-4
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![Methyltriphenylphosphonium bromide](/CAS/GIF/1779-49-3.gif)
1779-49-3
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$5.00/10g
![3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE](/CAS/GIF/130336-16-2.gif)
130336-16-2
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$7.00/100mg
![1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene](/CAS/20150408/GIF/864725-22-4.gif)
864725-22-4
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![Methyl triphenyl phosphonium chloride](/CAS/GIF/1031-15-8.gif)
1031-15-8
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$7.00/5g
![3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE](/CAS/GIF/130336-16-2.gif)
130336-16-2
305 suppliers
$7.00/100mg
![1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene](/CAS/20150408/GIF/864725-22-4.gif)
864725-22-4
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![Trifluoropropene](/CAS/GIF/677-21-4.gif)
677-21-4
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$35.00/25 g
![3,5-Dichlorophenylboronic acid](/CAS/GIF/67492-50-6.gif)
67492-50-6
333 suppliers
$6.00/1g
![1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene](/CAS/20150408/GIF/864725-22-4.gif)
864725-22-4
119 suppliers
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