2-OXO-1-PHENYL-1,2-DIHYDROPYRIDINE-3-CARBOXYLIC ACID synthesis

5synthesis methods

Product Name:2-OXO-1-PHENYL-1,2-DIHYDROPYRIDINE-3-CARBOXYLIC ACID
CAS Number:868171-81-7
Molecular formula:C12H9NO3
Molecular Weight:215.2

methyl 2-oxo-1-phenyl-1,2-dihydropyridine-3-carboxylate

868171-80-6
1 suppliers
inquiry

2-OXO-1-PHENYL-1,2-DIHYDROPYRIDINE-3-CARBOXYLIC ACID

868171-81-7
21 suppliers
$45.00/2.5mg

Yield:868171-81-7 86%

Reaction Conditions:

with lithium hydroxide monohydrate;water in tetrahydrofuran;methanol at 20; for 4 h;

Steps:

13 2-oxo-l-Phenyl-l, 2-dihydropyridine-3-carboxylic acid (Int-10)

A solution of compound Int-9 (800 mg, 3.5 mmol) in MeOH (2 mL), THF (6 mL) and H2O (2 mL) was treated with LiOH HiO (293 mg, 7.0 mmol) and the mixture was stirred at room temperature for 4 h. Then the mixture was concentrated under reduced pressure and the residue was diluted with water (8 mL). The pH of mixture was adjusted to 2 and the resulting suspension was filtered. The isolated solid was dried to afford the compound Int-10 (650 mg, 86%) as a yellow solid. ESI-MS (EI+, m/z): 216.10.

References:

WO2020/6233,2020,A1 Location in patent:Paragraph 0182; 0185-0186