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TERT-BUTYL 2-(1-(4-(ETHOXYCARBONYL)PHENYL)ETHYL)HYDRAZINECARBOXYLATE synthesis

4synthesis methods
(Z)-tert-butyl 2-(1-(4-(Methoxycarbonyl)phenyl)ethylidene)hydrazinecarboxylate

870822-87-0
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TERT-BUTYL 2-(1-(4-(ETHOXYCARBONYL)PHENYL)ETHYL)HYDRAZINECARBOXYLATE

870822-88-1
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Yield:870822-88-1 98%

Reaction Conditions:

with sodium cyanoborohydride;toluene-4-sulfonic acid in tetrahydrofuran;Inert atmosphere;

References:

Xiong, Yusheng;Guo, Jian;Candelore, Mari R.;Liang, Rui;Miller, Corey;Dallas-Yang, Qing;Jiang, Guoqiang;McCann, Peggy E.;Qureshi, Sajjad A.;Tong, Xinchun;Xu, Shiyao Sherrie;Shang, Jackie;Vincent, Stella H.;Tota, Laurie M.;Wright, Michael J.;Yang, Xiaodong;Zhang, Bei B.;Tata, James R.;Parmee, Emma R. [Journal of Medicinal Chemistry,2012,vol. 55,# 13,p. 6137 - 6148] Location in patent:experimental part