tert-butyl N-{2-[(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)oxy]ethyl}carbamate synthesis
- Product Name:tert-butyl N-{2-[(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)oxy]ethyl}carbamate
- CAS Number:87276-51-5
- Molecular formula:C15H18N2O5
- Molecular Weight:306.31
Yield:87276-51-5 95%
Reaction Conditions:
with triphenylphosphine;diethylazodicarboxylate in dichloromethane at 0 - 20;
Steps:
2 Example 2 Synthesis of Compound 3
The obtained compound 2 (1.6 g, 10 mmol),N-hydroxysuccinimide (1.79 g, 11 mmol)And triphenylphosphine (2.88 g, 11 mmol) were dissolved in 25 mL DCM,At 0 ° C,Then DEAD (1.92g, 11mmol) was added to the reaction system,After stirring at room temperature overnight,The solvent was spun dry to give pure product 3 (2.91 g, 95%).
References:
CN104248770,2017,B Location in patent:Paragraph 009; 0092
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