ChemicalBook CAS DataBase List 4-Formyl-3-iodobenzotrifluoride, 2-Iodo-alpha,alpha,alpha-trifluoro-p-tolualdehyde

4-Formyl-3-iodobenzotrifluoride, 2-Iodo-alpha,alpha,alpha-trifluoro-p-tolualdehyde synthesis

10synthesis methods

Product Name:4-Formyl-3-iodobenzotrifluoride, 2-Iodo-alpha,alpha,alpha-trifluoro-p-tolualdehyde
CAS Number:873006-01-0
Molecular formula:C8H4F3IO
Molecular Weight:300.02

Oxazole, 4,5-dihydro-2-[2-iodo-4-(trifluoromethyl)phenyl]-4,4-dimethyl-

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4-Formyl-3-iodobenzotrifluoride, 2-Iodo-alpha,alpha,alpha-trifluoro-p-tolualdehyde

873006-01-0
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$102.00/1g

Yield:873006-01-0 54%

Reaction Conditions:

Stage #1: 4,4-dimethyl-2-(2-iodo-4-trifluoromethylphenyl)-2-oxazolinewith methyl trifluoromethanesulfonate in dichloromethane at 20; for 2 h;Inert atmosphere;
Stage #2: with sodium tetrahydroborate in tetrahydrofuran;methanol;dichloromethane at 0; for 1 h;Inert atmosphere;Further stages;

References:

Takaya, Jun;Sangu, Kenichiro;Iwasawa, Nobuharu [Angewandte Chemie - International Edition,2009,vol. 48,# 38,p. 7090 - 7093][Angewandte Chemie,2009,vol. 121,# 38,p. 7090 - 7093] Location in patent:supporting information; experimental part

1259323-42-6 Synthesis