tert-butyl 3-(pyridin-3-yl)pyrrolidine-1-carboxylate synthesis
- Product Name:tert-butyl 3-(pyridin-3-yl)pyrrolidine-1-carboxylate
- CAS Number:874218-24-3
- Molecular formula:C14H20N2O2
- Molecular Weight:248.32
150281-46-2
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Yield:874218-24-3 100%
Reaction Conditions:
with sodium hydroxide in ethanol;water; pH=10; for 24 h;
Steps:
17.1
3-Pyrrolidine-3-yl pyridine (1.00 g, 6.74 mmol) was taken up in water (10 mL) and ethanol (10 mL). To this solution was added di-tert-butyl dicarbonate (3.21 g, 20.24 mmol) and then 1N aq NaOH (6 mL) to pH=10. The reaction solution was stirred for 24 hours and evaporated to dryness. The product (1.67 g, 100%) was used without further purification. ESI MS m/z 249.0 (M+H+).
References:
US2006/19985,2006,A1 Location in patent:Page/Page column 27
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