ChemicalBook CAS DataBase List (7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol

(7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol synthesis

5synthesis methods

Product Name:(7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol
CAS Number:875573-67-4
Molecular formula:C27H41BrO2
Molecular Weight:477.53

875573-66-3 Synthesis

(7a,17b)-7-(9-Bromononyl)-estra-1,3,5(10)-triene-3,17-diol 17-acetate

875573-66-3
146 suppliers
$117.00/5mg

(7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol

875573-67-4
151 suppliers
$65.00/50mg

Yield:-

Reaction Conditions:

with methanol;water;hydrogen bromide at 60; for 0.8 h;

Steps:

10

Example 10; Preparation of Cp 9354 from Cp 9342 (Depicted in FIG. 7); To 61.7 grams of Cp 9342 in 494 grams of methanol was added 123.4 grams of hydrobromic acid 48% and the mixture was heated at 60° C. for 0.8 hours. The mixture was slowly cooled to 5° C. and seeded with a crystal of Cp 9354. After 1 hour the suspension was filtered and the crystals rinsed with a cold mixture of 100 grams methanol and 30 grams of water. After drying under vacuum at 60° C. to constant weight, 46 grams of Cp 9354 were obtained.

References:

US2006/30552,2006,A1 Location in patent:Page/Page column 25

55362-80-6 Synthesis