4-(2-hydroxypropan-2-yl)-2-propyl-1-((2'-(2-trityl-2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-1H-imidazole-5-carboxylic acid synthesis
- Product Name:4-(2-hydroxypropan-2-yl)-2-propyl-1-((2'-(2-trityl-2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-1H-imidazole-5-carboxylic acid
- CAS Number:879097-59-3
- Molecular formula:C43H41N6NaO3
- Molecular Weight:712.83
![1H-IMidazole-5-carboxylic acid, 4-(1-hydroxy-1-Methylethyl)-2-propyl-1-[[2'-[1-(triphenylMethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]Methyl]-, ethyl ester](/CAS/GIF/144690-33-5.gif)
144690-33-5
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879097-59-3
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Yield:879097-59-3 100%
Reaction Conditions:
with sodium hydroxide in ethanol;water at 20 - 69;Large scale;Temperature;
Steps:
3 Example 3 Example 3 and Example 1 the difference between: the invention relates to a method for preparing olmesartan, comprises the following steps:
In step (2) in, 23.2 kg sodium hydroxide dissolved in 250 kg for use in water, 395 kg AMST - 3, 2000 kg of ethanol is added to the reactor, lowering the temperature to 20 °C, keep 20 °C sodium hydroxide aqueous solution, after the completion of the dropping the temperature to 69 °C reaction, TLC monitoring after the reaction is finished 80 °C water bath vacuum distilling 1700 kg of ethanol, lowering the temperature to 3 degrees, adding 1000 kg water, 100 kg sodium chloride, 1500 kg ethyl acetate stirring extraction, liquid, the lower layer of water for 100 kg ethyl acetate extraction, the combined organic phase, sodium chloride aqueous solution for washing, the water is 1000 kg, sodium chloride as 100 kg, the branching off of the upper organic phase, anhydrous sodium sulfate 50 kg drying, filtering, 70 °C following the pressure of the ethyl acetate, the obtained product is 391.6 kg, ywhich isld 100%
References:
CN107311989,2017,A Location in patent:Paragraph 0034; 0035; 0041; 0042; 0043; 0044; 0045; 0046
144689-93-0
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879097-59-3
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124750-51-2
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