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ChemicalBook CAS DataBase List 881673-98-9

881673-98-9 synthesis

3synthesis methods
-

Yield:881673-98-9 100%

Reaction Conditions:

Stage #1: ethyl 2-cyanoacetatewith potassium carbonate at 40 - 45; for 0.75 h;
Stage #2: 2-bromo-2'-fluoroacetophenone in acetone at 20; for 18 h;

References:

Arikawa, Yasuyoshi;Nishida, Haruyuki;Kurasawa, Osamu;Hasuoka, Atsushi;Hirase, Keizo;Inatomi, Nobuhiro;Hori, Yasunobu;Matsukawa, Jun;Imanishi, Akio;Kondo, Mitsuyo;Tarui, Naoki;Hamada, Teruki;Takagi, Terufumi;Takeuchi, Toshiyuki;Kajino, Masahiro [Journal of Medicinal Chemistry,2012,vol. 55,# 9,p. 4446 - 4456] Location in patent:experimental part