5-AMINO-1-BOC-3',4',5',6'-TETRAHYDRO-2'H-[2,4']BIPYRIDINYL synthesis
- Product Name:5-AMINO-1-BOC-3',4',5',6'-TETRAHYDRO-2'H-[2,4']BIPYRIDINYL
- CAS Number:885693-48-1
- Molecular formula:C15H23N3O2
- Molecular Weight:277.36
![[2,4'-Bipyridine]-1'(2'H)-carboxylic acid, 3',6'-dihydro-5-nitro-, 1,1-dimethylethyl ester](/CAS/20210305/GIF/885693-47-0.gif)
885693-47-0
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885693-48-1
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Yield:885693-48-1 100%
Reaction Conditions:
with hydrogen;palladium on activated carbon in methanol at 20; under 760.051 Torr; for 18 h;
Steps:
54.b
A solution of 226 mg (0.740 mmol) 5-nitro-3',6'-dihydro-2'H-[2,4']bipyridinyl-r- carboxylic acid tert-butyl ester (as prepared in the previous step) in 15 mL MeOH was treated with 110 mg 10 % Pd/C (Degussa type E101-NE/W, Aldrich, 50 % by weight water) and 1 atm H2 at room temperature for 18 h. The mixture was filtered through Celite, and the filter cake was washed with MeOH. Concentration afforded 220 mg (107 %) of the title compound as a colorless glassy solid. Mass spectrum (ESI, m/z): Calcd. for Ci5H23N3O2, 278.2 (M+H), found 278.0.
References:
WO2006/47277,2006,A2 Location in patent:Page/Page column 121
1085841-76-4
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885693-48-1
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4487-59-6
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885693-48-1
50 suppliers
$224.22/250mg