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ChemicalBook CAS DataBase List TERT-BUTYL 4-(BENZYLOXYMETHYL)-4-CYANOPIPERIDINE-1-CARBOXYLATE

TERT-BUTYL 4-(BENZYLOXYMETHYL)-4-CYANOPIPERIDINE-1-CARBOXYLATE synthesis

3synthesis methods
3587-60-8 Synthesis
Benzyl chloromethyl ether

3587-60-8
314 suppliers
$10.00/1g

91419-52-2 Synthesis
1-Boc-4-cyanopiperidine

91419-52-2
366 suppliers
$6.00/1g

TERT-BUTYL 4-(BENZYLOXYMETHYL)-4-CYANOPIPERIDINE-1-CARBOXYLATE

919284-64-3
21 suppliers
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Yield:919284-64-3 82%

Reaction Conditions:

Stage #1: 1-tert-butoxycarbonyl-4-cyanopiperidinewith potassium hexamethylsilazane in tetrahydrofuran at 25;
Stage #2: Benzyloxymethyl chloride in tetrahydrofuran;

References:

Zhao, Zhijian;O'Brien, Julie A.;Lemaire, Wei;Williams Jr., David L.;Jacobson, Marlene A.;Sur, Cyrille;Pettibone, Doug J.;Tiller, Philip R.;Smith, Sheri;Hartman, George D.;Wolkenberg, Scott E.;Lindsley, Craig W. [Bioorganic and Medicinal Chemistry Letters,2006,vol. 16,# 23,p. 5968 - 5972]