1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 5-(trifluoroMethyl)-, ethyl ester synthesis
- Product Name:1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 5-(trifluoroMethyl)-, ethyl ester
- CAS Number:920978-97-8
- Molecular formula:C11H9F3N2O2
- Molecular Weight:258.2
![5-(Trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid](/CAS/GIF/784144-05-4.gif)
784144-05-4
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Yield:920978-97-8 316 mg
Reaction Conditions:
with sulfuric acid at 85;
Steps:
2.3 3. Preparation of ethyl 5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylate
Concentrated sulfuric acid (0.5 mL) was added to absolute ethanol (10 mL) containing 5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid (0.6 g crude product), 85°C After reacting at for 16 hours, the reaction solution was directly spin-dried under reduced pressure, and the residue was subjected to silica gel column chromatography (petroleum ether: ethyl acetate = 3:1) to obtain the title compound (316 mg).
References:
WO2022/247839,2022,A1 Location in patent:Page/Page column 29-30
74784-70-6
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