![](/CAS/GIF/923009-50-1.gif)
TERT-BUTYL 1-OXO-2,7-DIAZASPIRO[4.5]DECANE-7-CARBOXYLATE synthesis
- Product Name:TERT-BUTYL 1-OXO-2,7-DIAZASPIRO[4.5]DECANE-7-CARBOXYLATE
- CAS Number:923009-50-1
- Molecular formula:C13H22N2O3
- Molecular Weight:254.33
![Di-tert-butyl dicarbonate](/CAS/GIF/24424-99-5.gif)
24424-99-5
825 suppliers
$13.50/25G
![2,7-DIAZASPIRO[4.5]DECAN-1-ONE HYDROCHLORIDE](/StructureFile/ChemBookStructure20/GIF/CB7815201.gif)
1187173-43-8
61 suppliers
$38.00/100mg
![TERT-BUTYL 1-OXO-2,7-DIAZASPIRO[4.5]DECANE-7-CARBOXYLATE](/CAS/GIF/923009-50-1.gif)
923009-50-1
82 suppliers
$106.00/250 mg
Yield: 100%
Reaction Conditions:
with triethylamine in dichloromethane at 20; for 4 h;Inert atmosphere;
Steps:
P44 Preparation 44: tert-butyl 1-oxo-2,7-diazaspiro[4,5]decane-7-carboxylate (P44)
Preparation 44: tert-butyl 1-oxo-2,7-diazaspiro[4,5]decane-7-carboxylate (P44)2,7-diazaspiro[4.5]decan-l-one hydrochloride (600 mg, 3.15 mmol), was dissolved in 30 m L of DCM. To this solution, TEA (1.98 mL, 14.18 mmol) and Boc20 (895 mg, 4.10 mmol) were added and the reaction mixture was stirred at RT for 4 hrs. Water was added and the two layers were separated; the organic layer was washed with NH4CI, dried and evaporated to obtain ferf-butyl l-oxo-2,7- diazaspiro[4.5]decane-7-carboxylate (p44, 830 mg, y= quant.), colourless oil.MS (ES) (m/z): 255.2 [M+H]+.
References:
SHIRE INTERNATIONAL GMBH;SEMERARO, Teresa;TARSI, Luca;MICHELI, Fabrizio;LUKER, Tim;CREMONESI, Susanna WO2016/42451, 2016, A1 Location in patent:Page/Page column 84
![1,3-Piperidinedicarboxylic acid, 3-(cyanomethyl)-, 1-(1,1-dimethylethyl) 3-ethyl ester](/CAS/GIF/923009-49-8.gif)
923009-49-8
12 suppliers
inquiry
![TERT-BUTYL 1-OXO-2,7-DIAZASPIRO[4.5]DECANE-7-CARBOXYLATE](/CAS/GIF/923009-50-1.gif)
923009-50-1
82 suppliers
$106.00/250 mg