TERT-BUTYL 1-OXO-2,7-DIAZASPIRO[4.5]DECANE-7-CARBOXYLATE synthesis
- Product Name:TERT-BUTYL 1-OXO-2,7-DIAZASPIRO[4.5]DECANE-7-CARBOXYLATE
- CAS Number:923009-50-1
- Molecular formula:C13H22N2O3
- Molecular Weight:254.33
24424-99-5
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![2,7-DIAZASPIRO[4.5]DECAN-1-ONE HYDROCHLORIDE](/StructureFile/ChemBookStructure20/GIF/CB7815201.gif)
1187173-43-8
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923009-50-1
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Yield: 100%
Reaction Conditions:
with triethylamine in dichloromethane at 20; for 4 h;Inert atmosphere;
Steps:
P44 Preparation 44: tert-butyl 1-oxo-2,7-diazaspiro[4,5]decane-7-carboxylate (P44)
Preparation 44: tert-butyl 1-oxo-2,7-diazaspiro[4,5]decane-7-carboxylate (P44)2,7-diazaspiro[4.5]decan-l-one hydrochloride (600 mg, 3.15 mmol), was dissolved in 30 m L of DCM. To this solution, TEA (1.98 mL, 14.18 mmol) and Boc20 (895 mg, 4.10 mmol) were added and the reaction mixture was stirred at RT for 4 hrs. Water was added and the two layers were separated; the organic layer was washed with NH4CI, dried and evaporated to obtain ferf-butyl l-oxo-2,7- diazaspiro[4.5]decane-7-carboxylate (p44, 830 mg, y= quant.), colourless oil.MS (ES) (m/z): 255.2 [M+H]+.
References:
SHIRE INTERNATIONAL GMBH;SEMERARO, Teresa;TARSI, Luca;MICHELI, Fabrizio;LUKER, Tim;CREMONESI, Susanna WO2016/42451, 2016, A1 Location in patent:Page/Page column 84
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923009-50-1
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$106.00/250 mg