![](/CAS/GIF/952480-32-9.gif)
2-(3-(TERT-BUTOXYCARBONYL)-3-AZASPIRO[5.5]UNDECAN-9-YL)ACETIC ACID synthesis
- Product Name:2-(3-(TERT-BUTOXYCARBONYL)-3-AZASPIRO[5.5]UNDECAN-9-YL)ACETIC ACID
- CAS Number:952480-32-9
- Molecular formula:C17H29NO4
- Molecular Weight:311.42
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
737 suppliers
$9.00/25ml
![2-(3-(TERT-BUTOXYCARBONYL)-3-AZASPIRO[5.5]UNDECAN-9-YL)ACETIC ACID](/CAS/GIF/952480-32-9.gif)
952480-32-9
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$417.30/250mg
![methyl 2-{3-azaspiro[5.5]undecan-9-yl}acetate hydrochloride](/CAS/20180629/GIF/1017540-91-8.gif)
1017540-91-8
28 suppliers
$60.00/500mg
Yield:-
Reaction Conditions:
Stage #1: methanolwith thionyl chlorideCooling with ice;
Stage #2: 2-(3-(tert-butoxycarbonyl)-3-azaspiro[5.5]undecan-9-yl)acetic acid in methanol at 20; for 48 h;
Steps:
79.1
Step 1.; Methanol (50 mL) was cooled in an ice bath and SOCl2 (2 mL) was added dropwise with stirring. After 15 min, 2-(3-(tert-butoxycarbonyl)-3-azaspiro[5.5]undecan-9-yl)acetic acid (0.34 g, purchased from WuXi Pharmatech) was added. The mixture was stirred at rt for 2 d and concentrated to afford methyl 2-(3-azaspiro[5.5]undecan-9-yl)acetate as its hydrochloride salt.
References:
US2011/34455,2011,A1 Location in patent:Page/Page column 60
![2-(3-(TERT-BUTOXYCARBONYL)-3-AZASPIRO[5.5]UNDECAN-9-YL)ACETIC ACID](/CAS/GIF/952480-32-9.gif)
952480-32-9
48 suppliers
$417.30/250mg
![2-(3-azaspiro[5.5]undecan-9-yl)acetic acid hydrochloride](/CAS/20200331/GIF/1356386-08-7.gif)
1356386-08-7
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![2-(3-(TERT-BUTOXYCARBONYL)-3-AZASPIRO[5.5]UNDECAN-9-YL)ACETIC ACID](/CAS/GIF/952480-32-9.gif)
952480-32-9
48 suppliers
$417.30/250mg
![3-Azaspiro[5.5]undecane-9-acetic acid, 3-(5-formyl-2-pyrazinyl)-](/CAS/20210305/GIF/1356386-27-0.gif)
1356386-27-0
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![2-(3-(TERT-BUTOXYCARBONYL)-3-AZASPIRO[5.5]UNDECAN-9-YL)ACETIC ACID](/CAS/GIF/952480-32-9.gif)
952480-32-9
48 suppliers
$417.30/250mg
![3-Azaspiro[5.5]undecane-9-acetic acid, 3-(5-formyl-2-thiazolyl)-](/CAS/20210305/GIF/1356386-28-1.gif)
1356386-28-1
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![2-(3-(TERT-BUTOXYCARBONYL)-3-AZASPIRO[5.5]UNDECAN-9-YL)ACETIC ACID](/CAS/GIF/952480-32-9.gif)
952480-32-9
48 suppliers
$417.30/250mg
![3-Azaspiro[5.5]undecane-9-acetic acid, 3-(5-formyl-2-pyridinyl)-](/CAS/20210305/GIF/1356386-07-6.gif)
1356386-07-6
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