3-Hydroxy-8-(trifluoromethyl)quinoline-4-carboxylic acid synthesis
- Product Name:3-Hydroxy-8-(trifluoromethyl)quinoline-4-carboxylic acid
- CAS Number:924633-55-6
- Molecular formula:C11H6F3NO3
- Molecular Weight:257.1654
88-17-5
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Yield:-
Steps:
Multi-step reaction with 3 steps
1: NH2OH*HCl; Na2SO4; aq. HCl / 55 °C
2: H2SO4 / 55 - 80 °C
3: 33 percent / KOH
References:
Kaila, Neelu;Janz, Kristin;Huang, Adrian;Moretto, Alessandro;DeBernardo, Silvano;Bedard, Patricia W.;Tam, Steve;Clerin, Valerie;Keith Jr., James C.;Tsao, Desirée H.H.;Sushkova, Natalia;Shaw, Gray D.;Camphausen, Raymond T.;Schaub, Robert G.;Wang, Qin [Journal of Medicinal Chemistry,2007,vol. 50,# 1,p. 40 - 64]
