1-Piperidinecarboxylic acid, 4-[2-[(Methylsulfonyl)oxy]ethyl]-4-[[(Methylsulfonyl)oxy]Methyl]-, 1,1-diMethylethyl ester synthesis

5synthesis methods

Product Name:1-Piperidinecarboxylic acid, 4-[2-[(Methylsulfonyl)oxy]ethyl]-4-[[(Methylsulfonyl)oxy]Methyl]-, 1,1-diMethylethyl ester
CAS Number:929301-95-1
Molecular formula:C15H29NO8S2
Molecular Weight:415.52

124-63-0
6 suppliers
$10.00/5g

236406-38-5 Synthesis

1-Piperidinecarboxylic acid, 4-(2-hydroxyethyl)-4-(hydroxyMethyl)-, 1,1-diMethylethyl ester

236406-38-5
17 suppliers
inquiry

1-Piperidinecarboxylic acid, 4-[2-[(Methylsulfonyl)oxy]ethyl]-4-[[(Methylsulfonyl)oxy]Methyl]-, 1,1-diMethylethyl ester

929301-95-1
6 suppliers
inquiry

Yield:929301-95-1 96%

Reaction Conditions:

with triethylamine in dichloromethane at 0; for 2 h;

Steps:

Preparation of compound 4To a solution of compound 3 (11O g, 0.43 mol) and Et₃N (300 g, 412 mL, 3.0 mol) in CH₂Cl₂ (1100 mL) was added dropwise MsCl (170 g, 117 mL, 1.49 mol) in an ice bath. After the addition, the mixture was stirred at the same temperature for 2 h. TLC showed the reaction was complete. The mixture was poured into ice-water (200 mL) and stirred for 10 min. The organic layer was separated and the aqueous layer was extracted with CH₂Cl₂ two times. The combined organic layers were washed with 1 N aq. HCl (200 mLX 3) and brine, dried over MgSO₄ and concentrated to give compound 4 (170 g, 96%) as brown syrup.

References:

WO2007/30061,2007,A1 Location in patent:Page/Page column 86; 87

3612-20-2 Synthesis

3612-20-2
482 suppliers
$6.00/10g

929301-95-1
6 suppliers
inquiry

References

1-BENZYL-4-CYANOMETHYL-PIPERIDINE-4-CARBONITRILE

86945-27-9
26 suppliers
inquiry

929301-95-1
6 suppliers
inquiry

References

1-BENZYL-4-CARBOXYMETHYL-PIPERIDINE-4-CARBOXYLIC ACID

40117-92-8
16 suppliers
$439.00/1g

929301-95-1
6 suppliers
inquiry

References

4-Piperidineethanol, 4-(hydroxymethyl)-1-(phenylmethyl)-

40118-06-7
1 suppliers
inquiry

929301-95-1
6 suppliers
inquiry

References