6-CHLORO-2-OXO-4-PHENYL-1,2-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER synthesis

5synthesis methods

Product Name:6-CHLORO-2-OXO-4-PHENYL-1,2-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER
CAS Number:93654-27-4
Molecular formula:C18H14ClNO3
Molecular Weight:327.76

719-59-5 Synthesis

719-59-5
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105-53-3
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6-CHLORO-2-OXO-4-PHENYL-1,2-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER

93654-27-4
17 suppliers
$90.00/250mg

Yield:93654-27-4 95%

Reaction Conditions:

with sodium triflate;acetic acid in neat (no solvent) at 110; for 3 h;Friedlaender Quinoline Synthesis;

Steps:

5.3 General procedure for the synthesis of substituted ethyl 2-oxo-4-phenyl-1,2-dihydroquinoline-3-carboxylate (3f, 3g)

To a round bottom flask substituted 2-aminobenzophenone (0.01mol), 10mol % sodium trifluoromethanesulfonate, 5mol % acetic acid, and diethyl malonate (0.012mol) added, and refluxed at 110°C till the reaction get completed. After completion of the reaction, the reaction mixture was adsorbed and loaded on silica gel (100-200) mesh column. The column was eluted with 15-25% ethyl acetate in hexane to give desired compound in yield ranging from 91 to 95%.

References:

Kumar, Gautam;Sathe, Asawari;Krishna, Vagolu Siva;Sriram, Dharmarajan;Jachak, Sanjay M. [European Journal of Medicinal Chemistry,2018,vol. 157,p. 1 - 13]