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5-BroMo-3-tert-butoxycarbonylaMino-thiophene-2-carboxylicacidMethylester synthesis

4synthesis methods
-

Yield:946604-99-5 92%

Reaction Conditions:

Stage #1: 3-(tert-butoxycarboxamido)thiophen-2-formic acid methyl esterwith lithium diisopropyl amide in tetrahydrofuran at -78;
Stage #2: with 1,2-dibromo-1,1,2,2-tetrafluoroethane in tetrahydrofuran;

References:

Chan, Laval;Das, Sanjoy K.;Reddy, T. Jagadeeswar;Poisson, Carl;Proulx, Melanie;Pereira, Oswy;Courchesne, Marc;Roy, Caroline;Wang, Wuyi;Siddiqui, Arshad;Yannopoulos, Constantin G.;Nguyen-Ba, Nghe;Labrecque, Denis;Bethell, Richard;Hamel, Martine;Courtemanche-Asselin, Philippe;L'Heureux, Lucille;David, Maud;Nicolas, Olivier;Brunette, Stephanie;Bilimoria, Darius;Bedard, Jean [Bioorganic and Medicinal Chemistry Letters,2004,vol. 14,# 3,p. 793 - 796]