BENZOIC ACID, 2-AMINO-5-FLUORO-3-METHYL-, METHYL ESTER synthesis
- Product Name:BENZOIC ACID, 2-AMINO-5-FLUORO-3-METHYL-, METHYL ESTER
- CAS Number:952479-98-0
- Molecular formula:C9H10FNO2
- Molecular Weight:183.18
952479-97-9
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Yield:952479-98-0 94%
Reaction Conditions:
with hydrogen;1% Pd/C in methanol; under 760.051 Torr; for 24 h;Inert atmosphere;
Steps:
9.C
Step C: A solution of methyl 5-fluoro-3-methyl-2-nitrobenzoate (8.4 g,39.4 mmol) from Step B above in methanol (150 mL) was purged with nitrogen.Palladium on charcoal was added to the solution and hydrogenation was carried out for 24 h at latm. The reaction mixture was filtered through a pad of Celite and washed with methanol. The filtrate was concentrated in vacuo to afford methyl 2-amino-5-fluoro-3- methylbenzoate (6.8 g, 94%) as a white solid. 1H NMR (500 MHz, DMSOd6) δ 7.32 (dd, J = 10.0, 3.0 Hz, IH), 7.17 (dd, J = 9.0, 3.0 Hz, IH), 6.40 (s, 2H), 3.80 (s, 3H), 2.13 (s, 3H); MS (ESI+) m/z 184 (M+H).
References:
WO2011/8572,2011,A2 Location in patent:Page/Page column 68-69
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518070-19-4
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$6.00/250mg
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