ChemicalBook CAS DataBase List 2-(4-(2-Methoxyethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2-(4-(2-Methoxyethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane synthesis

6synthesis methods

Product Name:2-(4-(2-Methoxyethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
CAS Number:959972-40-8
Molecular formula:C15H23BO4
Molecular Weight:278.15

39255-23-7 Synthesis

39255-23-7
42 suppliers
$22.00/250mg

73183-34-3
567 suppliers
$6.00/5g

2-(4-(2-Methoxyethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

959972-40-8
40 suppliers
$34.00/100mg

Yield:959972-40-8 78%

Reaction Conditions:

with palladium (II) [1,1'-bis(diphenylphosphanyl)ferrocene] dichloride;anhydrous potassium acetate in 1,4-dioxane at 80;Inert atmosphere;

Steps:

8.2 Step-2 The synthesis of 058-C: General Method I

To a mixture of 058-B (1 .36 g, 4 mmol), Bis(pinacolato)diborane (2.24 g, 6 mmol), and KOAc (1 .15 g, 8 mmol) in 1 , 4-dioxane (50 mL) was added Pd(dppf)Cl₂ (429 mg, 0.4 mmol), and the reaction mixture was purged with Ar, then stirred at 80°C overnight. After cooling to room temperature, it was diluted by water (200 mL) and extracted with EtOAc (2 x 100 mL). The organic extract was washed by brine (200 mL), dried over anhydrous Na₂SO₄ and evaporated under reduced pressure to give a residue. The residue was purified by column chromatography on silica gel (eluting with 20% EA in PE) to give 058-C (1 .3 g, 78% yield) as grey solid. LC/MS (ESI): m/z = 296 [M+18]⁺. RT = 1.78 min

References:

WO2022/133529,2022,A1 Location in patent:Paragraph 0302; 0560; 0562

6482-24-2 Synthesis