2-Pyrrolidinecarboxamide,1-(hydroxyacetyl)-,(S)-(9CI) synthesis
- Product Name:2-Pyrrolidinecarboxamide,1-(hydroxyacetyl)-,(S)-(9CI)
- CAS Number:96166-39-1
- Molecular formula:C7H12N2O3
- Molecular Weight:172.18
214398-99-9
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Yield: 93%
Reaction Conditions:
with sodium carbonate in acetone at 50; for 5 h;Temperature;
Steps:
1.2; 2.2 Step 2. Preparation of Compound II
10.0 g of Compound I and 20.0 g of sodium carbonate were added to acetone, and the mixture was heated to 50 ° C for 5 hours, filtered hot, and the filtrate was concentrated to slightly turbid, and 50 mL of isopropyl ether was added to precipitate a solid.Filter and dry the solid at 40 ° C to constant weight to give 8.4 gCompound II; yield 93.0%; HPLC purity 99.32%.
References:
Zhuhai Federation Pharmaceutical Co., Ltd.;Yin Bangzhi;Mao Jiaohuang;Xu Huafeng;Qiao Mingfu;Liang Qingyong CN109776372, 2019, A Location in patent:Paragraph 0064; 0069; 0070; 0071; 0072; 0085; 0090-0093
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