Acetamide, N-(1,3-dimethyl-1H-pyrazol-5-yl)- synthesis
- Product Name:Acetamide, N-(1,3-dimethyl-1H-pyrazol-5-yl)-
- CAS Number:75092-37-4
- Molecular formula:C7H11N3O
- Molecular Weight:153.18
3524-32-1
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108-24-7
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75092-37-4
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Yield:75092-37-4 100%
Reaction Conditions:
with pyridine at 0 - 20; for 0.5 h;
Steps:
16.i
Example 16; Synthesis of (S^-bis-trifluoromethyl-benzy^-t-Ccyclopentylmethyl-ethyl-amino)- ljS-dimethyl-lH-pyrazololS^-ZjJpyridine-S-ylmethyll-carbamic acid methyl ester; Step (i): Synthesis of N-(2,5-dimethyl-2H-pyrazol-3-yl)-acetamide; Pyridine (7,1 mL, 90 mmol) was added to a solution of 2,5-dimethyl-2H-pyrazol- 3-ylamine (10 g, 90 mmol) in acetic anhydride (46 mL) at 0 0C and the resulting mixture was stirred at room temperature for 30 min. The solvent was removed under vacuum to yield the title compound as a brownish liquid (13.7 g), yield: 100%. 1H ΝMR (400 MHz, CDC13): δ 7.91 (bs, IH), 5.98 (s, IH), 3.67-3.56 (m, 3H), 2.19-2.11 (m, 6H). ES-MS m/z 154 (M++ 1, 100%).
References:
WO2006/73973,2006,A2 Location in patent:Page/Page column 172
3524-32-1
183 suppliers
$5.00/250mg
127-08-2
625 suppliers
$6.00/25g
108-24-7
5 suppliers
$14.00/250ML
75092-37-4
16 suppliers
$185.00/1g