ADIPIC DIANILIDE synthesis

8synthesis methods

Product Name:ADIPIC DIANILIDE
CAS Number:4456-80-8
Molecular formula:C18H20N2O2
Molecular Weight:296.36

124-04-9 Synthesis

124-04-9
995 suppliers
$6.00/25g

62-53-3 Synthesis

62-53-3
636 suppliers
$10.00/1g

4456-80-8
14 suppliers
$12.00/1mg

Yield:4456-80-8 98%

Reaction Conditions:

with dmap;1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in chloroform at 20; for 10 h;Cooling with ice;Inert atmosphere;

Steps:

1

Adipic acid (manufactured by Wako Pure Chemical Co., Ltd. 15. 0g, 103mmol), aniline (Kishida Chemical Co., Ltd. 15. 9g, 171mmol) was weighed into a 3-mouth flask, and diluted to chloroform (180 ml), and ice-cooled under a nitrogen atmosphere. 1-(3-Dimethylaminopropyl)-3-Ethylcarbodiimide hydrochloride (Tokyo Kasei Co., Ltd. 39. 5g, 206mmol) and 4-di Methylaminopyridine (10mg) was added, and stirred for 10 hours at room temperature. Methanol (50ml) was added, and concentrated in an evaporator, the resulting residue methanol: Water = 1:1 (150ml) was washed with, dried the filtered resulting solids, compound as a white solid 2 (24. 8g, was obtained 98% yield.

References:

JP2018/58976,2018,A Location in patent:Paragraph 0211; 0214; 0215