AKOS B023993 synthesis

Yield:-

Reaction Conditions:

with 4-methylmorpholine N-oxide;sodium hydroxide in water at 80; for 3 h;Green chemistry;Overall yield = 70 %;Reagent/catalyst;

Steps:

Alkylation of 3-methylpyrazole (2) with haloalkanesin the NMO-H2O system (General method).

General procedure: The correspondingalkylating reagent (0.15 mol) was added dropwiseto a mixture of 3-methylpyrazole (2) (6.0 g, 0.15 mol),NaOH (6.0 g, 0.15 mol), and 50% aqueous NMO (50 ml),and stirred vigorously at the respective temperature for 3 h.The reaction mixture was extracted with CHCl3 (3×15 ml).After removal of the solvent, the residue was distilledunder reduced pressure. Yields and physicochemicalcharacteristics are given in Table 2.

References:

Hasratyan, Ani H.;Alexanyan, Ashkharuhi G.;Khachatryan, Hasmik N.;Zakaryan, Geghetsik B.;Hayotsyan, Sargis S.;Danagulyan, Gevorg G.;Attaryan, Hovhannes S. [Chemistry of Heterocyclic Compounds,2018,vol. 54,# 7,p. 751 - 754][Khim. Geterotsikl. Soedin.,2018,vol. 54,# 7,p. 751 - 754,4]