ChemicalBook CAS DataBase List Alicapistat (Synonyms: ABT-957)

Alicapistat (Synonyms: ABT-957) synthesis

5synthesis methods

Product Name:Alicapistat (Synonyms: ABT-957)
CAS Number:1254698-46-8
Molecular formula:C25H27N3O4
Molecular Weight:433.5

38854-94-3 Synthesis

38854-94-3
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1254698-46-8
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Yield:-

Steps:

Multi-step reaction with 4 steps
1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 0.17 h / 0 °C
1.2: 0 - 20 °C
2.1: sodium hydroxide / water; ethanol / 20 °C
3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.17 h / 0 °C
3.2: 0 - 20 °C
4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dichloro-acetic acid / dimethyl sulfoxide / 16 h / 20 °C

References:

Jantos, Katja;Kling, Andreas;Mack, Helmut;Hornberger, Wilfried;Moeller, Achim;Nimmrich, Volker;Lao, Yanbin;Nijsen, Marjoleen [Bioorganic and Medicinal Chemistry Letters,2019,vol. 29,# 15,p. 1968 - 1973]

ethyl 3-((R)-1-benzyl-5-oxopyrrolidine-2-carboxamido)-2-hydroxy-4-phenylbutanoate

1254699-98-3
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1254698-46-8
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References

6893-26-1
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$6.00/10g

1254698-46-8
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References

100-52-7 Synthesis

100-52-7
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$17.30/2g

1254698-46-8
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References

3-((R)-1-benzyl-5-oxopyrrolidine-2-carboxamido)-2-hydroxy-4-phenylbutanoicacid

1254699-99-4
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1254698-46-8
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References