ALPHA-ZEARALENOL synthesis
- Product Name:ALPHA-ZEARALENOL
- CAS Number:36455-72-8
- Molecular formula:C18H24O5
- Molecular Weight:320.38
17924-92-4
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71030-11-0
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$38.00/500μg
36455-72-8
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$55.00/1mg
Yield:71030-11-0 58% ，36455-72-8 29%
Reaction Conditions:
with sodium tetrahydroborate in methanol at 0 - 20; for 3 h;Inert atmosphere;
Steps:
Preparation of b- and a-Zearalenols
Toa solution of zearalenone (60.8 mg, 0.19 mmol) in MeOH (1 mL) at 0 °C wasslowly added NaBH4 (32.5 mg, 0.96 mmol, 4.5 equiv). The mixture wasstirred under argon from 0 °C to room temperature for 3 h. The reaction mixturewas then added 5 mL of H2O and extracted with EtOAc (4 × 5 mL). Thecombined organic layers were washed with brine, dried with anhydrous Na2SO4and concentrated in vacuo. Purification of the crude residue by columnchromatography (20% EtOAc/hexanes) gave a mixture of b- and a-zearalenols, whichwere further separated by reverse phase column chromatography using 70% MeOH/H2Oas an eluent to give b-zearalenol (2) and a-zearalenol (18).
References:
Tadpetch, Kwanruthai;Kaewmee, Benyapa;Chantakaew, Kittisak;Kantee, Kawalee;Rukachaisirikul, Vatcharin;Phongpaichit, Souwalak [Bioorganic and Medicinal Chemistry Letters,2016,vol. 26,# 15,p. 3612 - 3616] Location in patent:supporting information
17924-92-4
243 suppliers
$27.00/100mg
36455-72-8
77 suppliers
$55.00/1mg
![Decanal, 5,9-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (5S,9S)-](/CAS/20210305/GIF/311805-75-1.gif)
311805-75-1
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36455-72-8
77 suppliers
$55.00/1mg