![](/CAS/GIF/2114-02-5.gif)
Amidinothiourea synthesis
- Product Name:Amidinothiourea
- CAS Number:2114-02-5
- Molecular formula:C2H6N4S
- Molecular Weight:118.16
![Carbonocyanidimidic amide (9CI)](/CAS/20200611/GIF/37507-70-3.gif)
37507-70-3
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![Amidinothiourea](/CAS/GIF/2114-02-5.gif)
2114-02-5
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$6.00/10g
Yield:2114-02-5 80%
Reaction Conditions:
Stage #1:cyanocarboxamidine with hydrogenchloride in water at 20;
Stage #2: with ammonium hydroxide;Sodium thiosulfate pentahydrate in water at 0; for 1 h;
Steps:
19 1-[Amino(imino)methyl]thiourea (Guanyithiourea) (A):
To a solution ofdicyandiamide (1 g, 1.9 mmol) in water (250 ml) conc. HC1 (2.38 ml) was added dropwise over aperiod of 10 minutes by maintaining the reaction temperature below 20 °C. With continued stirring, a solution of sodium thiosulfate pentahydrate (2.98 g, 1.9 mmol) in water (125 ml ) was added dropwise over 30 minutes, by then the nearly insoluble gutimine hydrogen sulfate was precipitated out. After that pH of the mixture was adjusted to 8-10 by addition of ammonium hydroxide (2.86 ml,25%) at 0 °C. The obtained precipitate was collected, washed with cold water and dried to obtain2.25 g (80%) of compound A as colorless crystals. 1H NMR (DMSO-d6): 3 7.15 (brs, 3H, NH), 6.99 (brs, 3H, NH).
References:
VYOME BIOSCIENCES PVT. LTD.;SENGUPTA, Shiladitya;GHOSH, Shamik;GHOSH, Sumana;SINHA, Mau;SADHASIVAM, Suresh;BHATTACHARYYA, Anamika;MAVUDURU, Siva Ganesh;TANDON, Nupur;KUMAR, Deepak WO2017/17631, 2017, A2 Location in patent:Paragraph 00348
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17356-08-0
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2114-02-5
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7732-18-5
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504-66-5
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![Cyanamide](/CAS/GIF/420-04-2.gif)
420-04-2
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$15.00/25g
![Amidinothiourea](/CAS/GIF/2114-02-5.gif)
2114-02-5
253 suppliers
$6.00/10g