ChemicalBook CAS DataBase List AS1842856

AS1842856 synthesis

6synthesis methods

Product Name:AS1842856
CAS Number:836620-48-5
Molecular formula:C18H22FN3O3
Molecular Weight:347.38

3-Quinolinecarboxylic acid, 5-amino-1-ethyl-6,7-difluoro-1,4-dihydro-4-oxo-

131683-96-0
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108-91-8 Synthesis

108-91-8
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836620-48-5
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Yield: 9.6%

Reaction Conditions:

with triethylamine in dimethyl sulfoxide at 100; for 16 h;

Steps:

3 Synthesis of Compound 1-7.
To a solution of Compound 1-6 (0.5 g, 1.86 mmol) in DMSO (5 mL) was added cyclohexylamine (0.6 g, 5.6 mmol) and triethylamine (0.6 g, 5.6 mmol), then the mixture was stirred at 100 °C for 16 hours. The mixture was poured into ice water, filtered, the filter cake was washed with DMSO/H2O =1/1. The crude product was recrystallized from EtOH to give Compound 1-7 (58 mg, 9.6 %) as a yellow solid. NMR (DMSO-de, 400 MHz): d (ppm) 15.54 (s, IH), 8 62 (s, IH), 7.17 (s, 2H), 6.15 (s, IH), 6.01 (s, IH), 4.33 (s, 2H), 3.49 (s, IH), 1.90-1.93 (d, 2H, j 6.01 1/). 1.72-1.76 (m, 2.1 1).. 1.62-1.65 (m, IH), 1.27-1.44 (m, 7H), 1.14-1.20 (m, IH); MS: 348.2 [M+l]

References:

FREQUENCY THERAPEUTICS, INC.;TAIT, Bradley;HARRISON, Megan;MCLEAN, Will WO2020/163816, 2020, A1 Location in patent:Paragraph 00770; 00783-00784

163733-96-8 Synthesis

163733-96-8
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836620-48-5
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References

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
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836620-48-5
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References

3-Quinolinecarboxylic acid, 1-ethyl-6,7-difluoro-1,4-dihydro-4-oxo-5-[(phenylmethyl)amino]-, ethyl ester

836621-23-9
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836620-48-5
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References

3-Quinolinecarboxylic acid, 1-ethyl-5,6,7-trifluoro-1,4-dihydro-4-oxo-, ethyl ester

836620-49-6
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836620-48-5
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$26.00/1mg

References