ASISCHEM W27133 synthesis
- Product Name:ASISCHEM W27133
- CAS Number:36881-76-2
- Molecular formula:C10H13NO4S
- Molecular Weight:243.28
716-41-6
12 suppliers
$116.00/250mg
74-88-4
340 suppliers
$15.00/10g
36881-76-2
10 suppliers
$28.60/25mg
Yield:36881-76-2 90.7%
Reaction Conditions:
with caesium carbonate in N,N-dimethyl-formamide at 20; for 4 h;
Steps:
1
20.4 g of compound 2 was dissolved in 200 mL of DMF, 31.9 g of cesium carbonate and 13.9 g of methyl iodide were added. The reaction system was stirred at room temperature for 4 h, TLC followed the reaction. After completion of the reaction, the reaction system was added to 300 mL of ice water and the aqueous phase was extracted twice with 300 mL of ethyl acetate. The organic phases were combined, washed with 200 mL of water and saturated brine, and dried over anhydrous magnesium sulfate. After steaming the dry solvent, the residue was subjected to silica gel column chromatography (petroleum ether: ethyl acetate = 9: 1) to give 19.6 g of a white solid 3. Yield 90.7%. Melting point 55~56 °C .
References:
CN104447614,2017,B Location in patent:Paragraph 0009; 0015; 0017
134-20-3
580 suppliers
$18.00/25mL
36881-76-2
10 suppliers
$28.60/25mg
74-87-3
197 suppliers
$18.50/48622
716-41-6
12 suppliers
$116.00/250mg
36881-76-2
10 suppliers
$28.60/25mg