ChemicalBook CAS DataBase List Avatrombopag

Avatrombopag synthesis

6synthesis methods

Product Name:Avatrombopag
CAS Number:570406-98-3
Molecular formula:C29H34Cl2N6O3S2
Molecular Weight:649.65

Avatrombopag, also known as AKR-501, YM477, AS 1670542 or E5501, is a novel orally-active thrombopoietin (TPO) receptor agonist. AKR-501 specifically targeted the TPO receptor and stimulated megakaryocytopoiesis throughout the development and maturation of megakaryocytes just as rhTPO did. AKR-501 may be useful in the treatment of patients with thrombocytopenia. Synthetic Description Reference: Miao, Dezu; Hu, Qingwen; Cong, Chao; Cao, Yan; Yu, Zhibo; Wang, Hongguang. Preparation method of platelet increasing agent Avatrombopag. Assignee Reyoung Pharmaceutical Co., Ltd., Peop. Rep. China. CN 107383000. (2017).

Synthetic Routes

ROUTE 1

Reference: Miao, Dezu; Hu, Qingwen; Cong, Chao; Cao, Yan; Yu, Zhibo; Wang, Hongguang. Preparation method of platelet increasing agent Avatrombopag. Assignee Reyoung Pharmaceutical Co., Ltd., Peop. Rep. China. CN 107383000. (2017).

570407-10-2 Synthesis

570407-10-2
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570406-98-3
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Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: N-Bromosuccinimide / 1-methyl-pyrrolidin-2-one / 0.5 h
1.2: 5 h / 60 °C
2.1: thionyl chloride; N,N-dimethyl-aniline / dichloromethane / 1 h / -20 °C
2.2: 1 h / 20 °C
3.1: potassium hydroxide / isopropyl alcohol / 2 h / 60 °C

References:

CN107383000,2017,A

17766-28-8 Synthesis