![](/CAS/GIF/890707-28-5.gif)
Bardoxolone synthesis
- Product Name:Bardoxolone
- CAS Number:890707-28-5
- Molecular formula:C9H11ClN2O
- Molecular Weight:198.65
![Methyl 2-amino-3-methylbenzoate](/CAS/GIF/870997-57-2.gif)
870997-57-2
69 suppliers
$45.00/100mg
![Bardoxolone](/CAS/GIF/890707-28-5.gif)
890707-28-5
159 suppliers
$5.00/100mg
Yield:890707-28-5 85%
Reaction Conditions:
with hydrogenchloride;dihydrogen peroxide;acetic acid at 5 - 20;
Steps:
Step-4 : 2-Amino-5-chloro-N,3-dimethylbenzamide
To a solution of 2-amino-N,3-dimethylbenzamide (4 g, 0.023) and hydrochloric acid (8 ml) in acetic acid (12 ml) was added hydrogen peroxide (30%, 0.032 mol) at 5-10°C. The reaction mixture was stirred for 5-6 h at room temperature. The progress of the reaction was monitored by HPLC. After completion of the reaction, water was added into the reaction mixture. The resultant solid product was isolated by filtration and washed with water. Yield: 85% and purity: 95%.
References:
EUROFINS ADVINUS LIMITED WO2021/33172, 2021, A1 Location in patent:Page/Page column 9; 16-17
![2-Amino-5-chloro-3-methylbenzoic acid](/CAS/GIF/20776-67-4.gif)
20776-67-4
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$6.00/5g
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74-89-5
7 suppliers
$13.44/25ML
![Bardoxolone](/CAS/GIF/890707-28-5.gif)
890707-28-5
159 suppliers
$5.00/100mg
![2H-3,1-Benzoxazine-2,4(1H)-dione, 6-chloro-8-methyl-](/CAS/GIF/120374-68-7.gif)
120374-68-7
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![Methylamine hydrochloride](/CAS/GIF/593-51-1.gif)
593-51-1
530 suppliers
$21.00/100g
![Bardoxolone](/CAS/GIF/890707-28-5.gif)
890707-28-5
159 suppliers
$5.00/100mg
201230-82-2
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![2-BROMO-4-CHLORO-6-METHYLANILINE](/CAS/GIF/146948-68-7.gif)
146948-68-7
68 suppliers
$67.00/10g
![Methylamine](/CAS/GIF/74-89-5.gif)
74-89-5
7 suppliers
$13.44/25ML
![Bardoxolone](/CAS/GIF/890707-28-5.gif)
890707-28-5
159 suppliers
$5.00/100mg
![2H-3,1-Benzoxazine-2,4(1H)-dione, 6-chloro-8-methyl-](/CAS/GIF/120374-68-7.gif)
120374-68-7
7 suppliers
inquiry
![Methylamine](/CAS/GIF/74-89-5.gif)
74-89-5
7 suppliers
$13.44/25ML
![Bardoxolone](/CAS/GIF/890707-28-5.gif)
890707-28-5
159 suppliers
$5.00/100mg