Benzo[b][1,8]naphthyridine synthesis

10synthesis methods

Product Name:Benzo[b][1,8]naphthyridine
CAS Number:90903-64-3
Molecular formula:C14H14N2
Molecular Weight:210.27

3-Pyridinemethanol, α,α-dimethyl-2-(phenylamino)-

90903-73-4
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90903-64-3
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Yield:90903-64-3 40%

Reaction Conditions:

with polyphosphoric acid in dichloromethane at 20;Reflux;

Steps:

1.1

2- (2- (phenylamino) pyridin-3-yl) propan-2-ol (69 g, 300 mmol) in a round-And polyphosphoric acid (60 g) were dissolved in MC and incubated for 48 hours at room temperatureAnd the mixture was refluxed and stirred. After completion of the reaction, the reaction solution was added to ice water and extracted several times with MC.After concentration of the solvent, the column was purified (MEOH 1% in MC), and the solvent was removed, and then, using MC / Pet.EtherAnd 25.5 g (yield 40%) of 5,5-dimethyl-5,10-dihydrobenzo [b] [1,8] naphthyridine was obtained by precipitation.

References:

KR2018/65486,2018,A Location in patent:Paragraph 0082; 0086; 0091; 0092

62-53-3 Synthesis