Benzofuran-3-carboxylic acid methyl ester synthesis

8synthesis methods

Product Name:Benzofuran-3-carboxylic acid methyl ester
CAS Number:4687-24-5
Molecular formula:C10H8O3
Molecular Weight:176.17

methyl 2,3-dihydro-1-benzofuran-3-carboxylate

39891-56-0
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Benzofuran-3-carboxylic acid methyl ester

4687-24-5
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$45.00/10mg

Yield:4687-24-5 93%

Reaction Conditions:

with 2,3-dicyano-5,6-dichloro-p-benzoquinone in dichloromethane at 20; for 48 h;

Steps:

4

A mixture of dihydrobezofuran a (Davies, H. M. L.; Grazini, M. V. A.; Aouad, E. Org. Lett. 2001, 3, 1475) (160 mg, 0.9 mmol) DDQ (300 mg) and CH₂Cl₂ (11 mL) was maintained at room temp, for 2 days. The solution was diluted with 50% ethyl acetate-hexanes and washed with 0.5 N NaOH (3 x 10 mL), brine (1 x 10 mL), dried (Na₂SO₄), filtered, and concentrated to afford 150 mg (93%) of bezofuran b.

References:

WO2006/69063,2006,A1 Location in patent:Page/Page column 60

533-58-4 Synthesis