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benzofuran-7-carbonitrile synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C
1.2: 2 h / 130 °C
2.1: phosphoric acid / chlorobenzene / 2.5 h / Reflux
3.1: copper(l) iodide / N,N-dimethyl-formamide / 4 h / 150 °C

References:

WO2015/95261,2015,A1