BENZYL-PYRIDIN-2-YLMETHYL-AMINE synthesis
- Product Name:BENZYL-PYRIDIN-2-YLMETHYL-AMINE
- CAS Number:18081-89-5
- Molecular formula:C13H14N2
- Molecular Weight:198.26
3731-51-9
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100-52-7
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18081-89-5
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Yield:18081-89-5 100%
Reaction Conditions:
Stage #1: 2-(Aminomethyl)pyridine;benzaldehyde in methanol at 20; for 2 h;
Stage #2: with methanol;sodium tetrahydroborate at 20; for 1 h;Cooling with ice;
Steps:
1.i (i) Synthesis of 1a
A mixture of 2-picolylamine (0.41 ml, 4.0 mmol) and benzaldehyde (0.4 ml, 4.0 mmol) in 40 ml MeOH was stirred at room temperature for 2 hours.
The solution was cooled in an ice bath, NaBH4 (0.3 g, 8 mmol) was added in small portions.
The mixture was slowly warmed to room temperature, and stirred for 1 hour.
Solvent was removed and the residue was re-dissolved in CH2Cl2, washed with saturated K2CO3 solution twice and with a solution of brine and dried over MgSO4.
Solvents were removed by a rotatory evaporator to give benzyl-pyridin-2-ylmethyl-amine (1a) which was used in the next step without further purification. Yield=0.79 g, quant.
References:
US10018623,2018,B1 Location in patent:Page/Page column 46; 47; 48
1121-60-4
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18081-89-5
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$199.81/250mg
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18081-89-5
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18081-89-5
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100-47-0
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18081-89-5
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$199.81/250mg