ChemicalBook CAS DataBase List β-Cyclodextrin

β-Cyclodextrin synthesis

9synthesis methods

Product Name:β-Cyclodextrin
CAS Number:7585-39-9
Molecular formula:C42H70O35
Molecular Weight:1134.99

Usually produced commercially from Bacillus macerans or B. circulans fermentation of starch or starch hydrolysate.

Mono-6-O-(p-toluenesulfonyl)-beta-cyclodextrin

67217-55-4
95 suppliers
$45.00/5mg

6-Monodeoxy-6-monoamino-beta-cyclodextrine

29390-67-8
76 suppliers
$50.00/100mg

7585-39-9
543 suppliers
$13.50/25G

Yield:29390-67-8 70% ，7585-39-9 30%

Reaction Conditions:

with ammonia in water at 60; for 5 h;Product distribution / selectivity;

Steps:

2

Compound 2 (3.0 g, 2.33 mmol) was dissolved in 50 ml concentrated NH₄OH solution. The reaction mixture was stirred at 60° C. for 5 h, cooled to room temperature and poured into 500 ml acetone to give a white precipitate. TLC analysis performed on silica plates (EtOAc:2-propanol:conc. NH₄OH:water-7:7:5:4) showed a mixture of product 4 (70%) and β-CD 1 (30%). The product 4 was recrystallized from ethanol-water (3:7). The ¹H NMR data are as in Example 1.

References:

US2008/275139,2008,A1 Location in patent:Page/Page column 11