Sulbactam Impurity 8 synthesis

4synthesis methods

Product Name:Sulbactam Impurity 8
CAS Number:75527-88-7
Molecular formula:C8H10BrNO5S
Molecular Weight:312.14

7732-18-5
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76646-91-8 Synthesis

(3S)-6,6-DIBROMO-2,2-DIMETHYLPENAM-3-CARBOXYLIC ACID 1,1-DIOXIDE

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Yield:-

Reaction Conditions:

with sodium hydrogen sulfate in sodium hydrogencarbonate;ethyl acetate;

Steps:

1 6-alpha-Bromopenicillanic Acid 1,1-Dioxide

EXAMPLE 1 6-alpha-Bromopenicillanic Acid 1,1-Dioxide To 6,6-dibromopenicillanic acid 1,1-dioxide (117.3 g, 0.3 mole), stirring in a mixture of H₂ O (600 mL) and ethyl acetate (400 mL), was added in portions NaHCO₃ (75.6 g, 0.9 mole) and then NaHSO₃ (37.5 g, 0.36 mole). After stirring 1 hour, the pH was adjusted from 3.7 to 1.5 with concentrated HCl. The aqueous layer was separated and extracted 1*400 mL with fresh ethyl acetate. The combined organic layers were backwashed with brine, dried and evaporated to yield title product as a solid; 72 g (76.7%); m.p. 136°-137°, pnmr/D₂ O-NaHCO₃ /delta: 1.48 (s, CH₃), 1.62 (s, CH₃), 4.28 (s, C.3--H), 5.12 (d, J=1.7, C.6--H), 5.37 (d, J=1.7, C.5--H).

References:

US4468351,1984,A

76646-91-8 Synthesis

76646-91-8
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$165.00/25mg

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References

24138-28-1 Synthesis