BIPHENYLACETICACID synthesis
- Product Name:BIPHENYLACETICACID
- CAS Number:23948-77-8
- Molecular formula:C14H12O2
- Molecular Weight:212.24
1878-67-7
336 suppliers
$5.00/5g
98-80-6
741 suppliers
$5.00/5g
23948-77-8
29 suppliers
$64.34/0.25g
Yield:23948-77-8 99%
Reaction Conditions:
with tetrakis(triphenylphosphine) palladium(0);sodium carbonate in 1,2-dimethoxyethane at 100; for 16 h;Inert atmosphere;
Steps:
5.1.14. 3-Biphenylacetic acid (36)
To a stirred solution of (3-bromo)phenylacetic acid (4.00 g, 18.26 mmol), Na2CO3 (2.13 g, 20.1 mmol) and phenylborinic acid (2.45 g, 20.1 mmol) in DME (45 mL) was added tetrakis-triphenylphosphine palladium (200 mg) at room temperature under argon atmosphere. After being stirred at 100 °C for 16 h, the reaction mixture was cooled to room temperature and filtered through Celite to remove the precipitates. The filtrate was diluted with EtOAc, washed with 2 N hydrochloric acid, brine, dried over MgSO4 and evaporated to afford 36 as a pale yellow powder (3.82 g, 99%). 1H NMR (300 MHz, CDCl3): δ 3.72 (s, 2H), 7.25-7.62 (m, 9H).
References:
Kambe, Tohru;Maruyama, Toru;Nagase, Toshihiko;Ogawa, Seiji;Minamoto, Chiaki;Sakata, Kiyoto;Maruyama, Takayuki;Nakai, Hisao;Toda, Masaaki [Bioorganic and Medicinal Chemistry,2012,vol. 20,# 2,p. 702 - 713] Location in patent:experimental part
75852-28-7
6 suppliers
inquiry
23948-77-8
29 suppliers
$64.34/0.25g
![[1,1'-Biphenyl]-3-acetic acid, phenylmethyl ester](/CAS/20210305/GIF/220099-04-7.gif)
220099-04-7
0 suppliers
inquiry
23948-77-8
29 suppliers
$64.34/0.25g
![[1,1'-Biphenyl]-3-acetic acid, ethyl ester](/CAS/20180529/GIF/71912-70-4.gif)
71912-70-4
4 suppliers
inquiry
23948-77-8
29 suppliers
$64.34/0.25g
![2-[(1,1'-Biphenyl)-3-yl]ethanol](/CAS/GIF/71912-71-5.gif)
71912-71-5
11 suppliers
$220.00/0.5g
23948-77-8
29 suppliers
$64.34/0.25g