![](/CAS/GIF/153086-78-3.gif)
Boc-1-amino-3,6-dioxa-8-octanediamine synthesis
- Product Name:Boc-1-amino-3,6-dioxa-8-octanediamine
- CAS Number:153086-78-3
- Molecular formula:C11H24N2O4
- Molecular Weight:248.32
![1,8-Diamino-3,6-dioxaoctane](/CAS/GIF/929-59-9.gif)
929-59-9
197 suppliers
$8.00/5g
![Di-tert-butyl dicarbonate](/CAS/GIF/24424-99-5.gif)
24424-99-5
825 suppliers
$13.50/25G
![Boc-1-amino-3,6-dioxa-8-octanediamine](/CAS/GIF/153086-78-3.gif)
153086-78-3
204 suppliers
$19.00/100mg
Yield:153086-78-3 100%
Reaction Conditions:
in dichloromethane at 0 - 20; for 23 h;Inert atmosphere;
Steps:
1.1. Mono-protection of 10
General procedure: The diamine 10 (1 equiv) in DCM solution (10 mL / mmol) was treated with Boc2O in default (0.15 equiv) for 5 h at 0 °C and 18 h at room temperature. The organic phase was washed with water, until all the unreacted 10 was extracted. The Boc-protected compound 11 was quantitatively recovered after drying (MgSO4) and concentration under vacuum. 11a: 1H NMR (300 MHz, CDCl3): d 1.45 (s, 9H), 1.80 (br m, 2H, NH2), 3.25 (m, 2H), 3.38 (m, 2H), 3.50-3.70 (m, 8H), 5.10 (br s, 1H, NHCO2). 11b: 1H NMR (300 MHz, CDCl3): d 1.42 (s, 9H), 1.75 (br m, 2H, NH2), 2.84 (t, 2H, J = 5.3 Hz), 3.29 (m, 2H), 3.51 (m, 4H), 3.58 (sharp m, 8H), 5.30 (br s, 1H, NHCO2).
References:
Favre, Annaïck;Grugier, Jérôme;Brans, Alain;Joris, Bernard;Marchand-Brynaert, Jacqueline [Tetrahedron,2012,vol. 68,# 52,p. 10818 - 10826] Location in patent:supporting information
![t-Boc-N-Amido-PEG2-Azide](/CAS/20210111/GIF/950683-55-3.gif)
950683-55-3
53 suppliers
$60.00/100mg
![Boc-1-amino-3,6-dioxa-8-octanediamine](/CAS/GIF/153086-78-3.gif)
153086-78-3
204 suppliers
$19.00/100mg
![1,8-Diamino-3,6-dioxaoctane](/CAS/GIF/929-59-9.gif)
929-59-9
197 suppliers
$8.00/5g
![Di-tert-butyl dicarbonate](/CAS/GIF/24424-99-5.gif)
24424-99-5
825 suppliers
$13.50/25G
![Boc-1-amino-3,6-dioxa-8-octanediamine](/CAS/GIF/153086-78-3.gif)
153086-78-3
204 suppliers
$19.00/100mg
![Boc-NH-PEG2-NH-Boc](/CAS/20200515/GIF/475591-59-4.gif)
475591-59-4
34 suppliers
$449.00/1g
![1,8-Diamino-3,6-dioxaoctane](/CAS/GIF/929-59-9.gif)
929-59-9
197 suppliers
$8.00/5g
![Carbonochloridic acid, 1,1-diMethylethyl ester](/CAS/GIF/24608-52-4.gif)
24608-52-4
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153086-78-3
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$19.00/100mg
![5,8-Dioxa-2,11-diazadodecanedioic acid, 1-(1,1-dimethylethyl) 12-(phenylmethyl) ester](/CAS/20210305/GIF/796865-54-8.gif)
796865-54-8
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![Boc-1-amino-3,6-dioxa-8-octanediamine](/CAS/GIF/153086-78-3.gif)
153086-78-3
204 suppliers
$19.00/100mg