ChemicalBook CAS DataBase List BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER

BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER synthesis

6synthesis methods

Product Name:BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER
CAS Number:166410-05-5
Molecular formula:C14H23NO5
Molecular Weight:285.34

170850-75-6
60 suppliers
$75.70/250MG

166410-05-5
158 suppliers
$55.00/1g

Yield: 92.74%

Reaction Conditions:

with 4-methylmorpholine N-oxide in dichloromethane at 20; for 1.5 h;Reagent/catalyst;

Steps:

1.2
(2) 17.36 g of the compound hydrazine was dissolved in dichloromethane, and 9.45 g of N-methyl_N_oxidized morpholine was added and stirred at room temperature for 1.5 hours, and the reaction completely gave a black turbid liquid, and the reaction solution was filtered off to remove insoluble matter. The filtrate was evaporated to dryness and purified by column chromatography to yield 16.75 g of white solid compound m, yield 92.74%

References:

Tierxi (Nanjing) Pharmaceutical Research And Development Co., Ltd.;He Xu;Wang Jiayan;Zhang Chi;Liu Chun;Cui Xilin CN110028496, 2019, A Location in patent:Paragraph 0056; 0059; 0069

84348-37-8 Synthesis