BOC-ASP-NH2 synthesis
- Product Name:BOC-ASP-NH2
- CAS Number:74244-17-0
- Molecular formula:C9H16N2O5
- Molecular Weight:232.23
![Butanoic acid, 4-amino-3-[[(1,1-dimethylethoxy)carbonyl]amino]-4-oxo-, phenylmethyl ester, (3S)-](/CAS/20210111/GIF/87421-27-0.gif)
87421-27-0
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74244-17-0
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$81.54/1G
Yield:74244-17-0 80%
Reaction Conditions:
with 5%-palladium/activated carbon;hydrogen in methanol;ethanol;N,N-dimethyl-formamide; for 24 h;
Steps:
N-t-Butyloxycarbonyl-L-aspartic acid a-amide (8)
N-t-Butyloxycarbonyl-L-aspartic acid (4.01 g, 12 mmol) was dissolved in a solution of methanol (50 mL), ethanol (20 mL) and N,N-dimethyl formamide (30 mL). The solution was stirred in a hydrogen atmosphere over 5 % palladium on charcoal for 24 h. After filtration of the reaction mixture, the filtrate was evaporated to give 2.3 g (80 %). m.p: 138-139 °C. Elemental analysis: Calcd. for C9H16N2O5: C, 46.55; H, 6.94;N, 12.06 %. Found: C, 46.21; H, 6.96; N, 11.78 %. [a]D25 + 52 (c = 0.44, ethanol-DMF (1:1)).
References:
Munegumi;Akao;Kawatu;Yamada;Harada [Asian Journal of Chemistry,2014,vol. 26,# 19,p. 6541 - 6548]
1070-19-5
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28057-52-5
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74244-17-0
58 suppliers
$81.54/1G