1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate synthesis
- Product Name:1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate
- CAS Number:203866-14-2
- Molecular formula:C10H16FNO4
- Molecular Weight:233.24
203866-18-6
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203866-14-2
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Yield:-
Steps:
G
The fluorination of the above cis-hydroxy provides the trans-4-fluoro derivative which on saponification gives the corresponding acid. The amine is prepared from 4-R-fluoro-pyrrolidine-1-carboxylic acid tert-butyl ester and 5-methyl-pyridin-2-ylamine under HATU condition to give proline amide derivative which on treatment with 4 M HCl in dioxane provides the desired amine.
References:
US2009/62537,2009,A1 Location in patent:Page/Page column 10
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203866-14-2
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203866-14-2
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