ChemicalBook CAS DataBase List Bromo-PEG4-t-butyl ester

Bromo-PEG4-t-butyl ester synthesis

5synthesis methods

Product Name:Bromo-PEG4-t-butyl ester
CAS Number:564476-32-0
Molecular formula:C15H29BrO6
Molecular Weight:385.29

581065-94-3
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$135.00/1G

564476-32-0
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$90.00/50mg

Yield: 90%

Reaction Conditions:

with lithium bromide in N,N-dimethyl-formamide at 80; for 1 h;

Steps:

88.8 (8) Synthesis of Compound 118:
Compound 117 (10 g, 21.0 mmol) and lithium bromide (4.8 g, 31.5 mmol) were dissolved in 30 mL of N,N-dimethylformamide and heated to 80 °C for 1 h. Rotary evaporation under reduced pressure and N,N- dimethylformamide, water and extracted three times with dichloromethane, the organic phases were combined and dried over anhydrous sodium sulfate, and rotary evaporation under reduced pressure, Column chromatography (CH2C12), to give a pale yellow liquid, i.e., compound 118 (7.3g, 90%).

References:

Zhongshan Guang He Medical Treatment Technology Co., Ltd.;Zhu Linyong;Hua Yujie;Lin Qiuning;Zhang Yiqing;Bao Chunyan;Zhong Xuepeng CN109776451, 2019, A Location in patent:Paragraph 0668; 0669; 0678

558-13-4 Synthesis