ChemicalBook CAS DataBase List BUTYL (S)-(-)-2-PYRROLIDONE-5-CARBOXYLATE

BUTYL (S)-(-)-2-PYRROLIDONE-5-CARBOXYLATE synthesis

5synthesis methods

Product Name:BUTYL (S)-(-)-2-PYRROLIDONE-5-CARBOXYLATE
CAS Number:4931-68-4
Molecular formula:C9H15NO3
Molecular Weight:185.22

98-79-3 Synthesis

98-79-3
598 suppliers
$5.00/25g

71-36-3 Synthesis

71-36-3
1023 suppliers
$14.00/25mL

BUTYL (S)-(-)-2-PYRROLIDONE-5-CARBOXYLATE

4931-68-4
19 suppliers
$30.28/5ML

Yield:4931-68-4 89%

Reaction Conditions:

with thionyl chloride at 20; for 12 h;

Steps:

4.2.1. General procedure for the synthesis of L-pyroglutamic acid esters (1a-1h)

General procedure: To a solution of L-pyroglutamic acid (10 mmol) in anhydrous alcohol(30 mL) was added catalytic amount of SOCl2 (1 mmol). The reaction mixture was stirred at room temperature for 12 h until no change was observed by TLC. After evaporating the solvent under reduced pressure, the residue was dissolved in EtOAc (100 mL), stirred over K2CO3, and dried with MgSO4 to afford the crude product. Then the residue passed through a flash column chromatography (MeOH/CH2Cl2=1/10) on silica gel and removal of all volatiles were in vacuo to give the pure products.

References:

Gang, Fang-li;Zhu, Feng;Li, Xiao-ting;Wei, Jie-lu;Wu, Wen-jun;Zhang, Ji-wen [Bioorganic and Medicinal Chemistry,2018,vol. 26,# 16,p. 4644 - 4649]

56-86-0 Synthesis