ChemicalBook CAS DataBase List Cabazitaxel Impurity 32 (Mixture of Diastereomers)

Cabazitaxel Impurity 32 (Mixture of Diastereomers) synthesis

1synthesis methods

Product Name:Cabazitaxel Impurity 32 (Mixture of Diastereomers)
CAS Number:949459-78-3
Molecular formula:C22H25NO6
Molecular Weight:399.44

949459-79-4
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Cabazitaxel Impurity 32 (Mixture of Diastereomers)

949459-78-3
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Yield:949459-78-3 89%

Reaction Conditions:

Stage #1: methyl (4S,5S)-3-(tert-butoxycarbonyl)-2-(p-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-methanoatewith water;potassium carbonate in methanol at 20; for 20 h;
Stage #2: with hydrogenchloride in methanol;dichloromethane;water at 0; pH=1;

References:

Prevost, Sebastien;Gauthier, Sebastien;De Andrade, Maria Cristina Cano;Mordant, Celine;Touati, Ali Rhida;Lesot, Philippe;Savignac, Philippe;Ayad, Tahar;Phansavath, Phannarath;Ratovelomanana-Vidal, Virginie;Genet, Jean-Pierre [Tetrahedron Asymmetry,2010,vol. 21,# 11-12,p. 1436 - 1446] Location in patent:experimental part

Cabazitaxel Impurity 32 (Mixture of Diastereomers) Related Search:

(αR,βS)-β-[[(1,1-DiMethylethoxy)carbonyl]aMino]-α-hydroxy-4-(phenylMethoxy)-benzenepropanoic Acid Ethyl Ester Epothilone B 6-CHLORO-4-CHLOROMETHYL-7-HYDROXY-CHROMEN-2-ONE (4S,5R)-2,2-DiMethyl-4-[4-(phenylMethoxy)phenyl]-N-DiMethylethoxycarbonyl-3,5-oxazolidinecarboxylic Acid Ethyl Ester (3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic Acid Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate (4S,5R)-2,2-DiMethyl-4-[4-(phenylMethoxy)phenyl]-3,5-oxazolidinedicarboxylic Acid 3-(1,1-DiMethylethyl) Ester 2-Bromobenzene-1,3-dialdehyde 4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-8-(phenylsulfonyl)undeca-1,5-dienyl]-2-methyl-1,3-thiazole 2'-O-(tert-Butyldimethylsilyl)-6,7-dehydropaclitaxel