CAY10590 synthesis

Yield:1101136-50-8 90%

Reaction Conditions:

Stage #1: (R)-ethyl 4-(7-phenylheptanamido)octanoatewith sodium hydroxide;water in 1,4-dioxane at 20; for 12 h;
Stage #2: with hydrogenchloride in water;

References:

Antonopoulou, Georgia;Barbayianni, Efrosini;Magrioti, Victoria;Cotton, Naomi;Stephens, Daren;Constantinou-Kokotou, Violetta;Dennis, Edward A.;Kokotos, George [Bioorganic and Medicinal Chemistry,2008,vol. 16,# 24,p. 10257 - 10269] Location in patent:experimental part