CHEMBRDG-BB 5851236 synthesis
- Product Name:CHEMBRDG-BB 5851236
- CAS Number:99851-80-6
- Molecular formula:C11H9BrN2O
- Molecular Weight:265.11
33757-42-5
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99851-80-6
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Yield:99851-80-6 98%
Reaction Conditions:
with N-benzyl-N,N,N-triethylammonium chloride;N,N'-dibromohydantoin in water at 20; for 12 h;
Steps:
2; 21; 22 Example 22
This example is the amplification reaction of Example 2. The preparation method of an 8-amide-5-haloquinoline derivative of the present invention is used to prepare N-(5-bromoquinolin-8-yl)acetamide (1ab ), the English name is N-(5-bromoquinolin-8-yl)acetamide(1ab), and its chemical reaction formula is as follows:The specific steps are as follows: Put 8-acetylaminoquinoline (1.86g, 0.01mol), dibromohydantoin (1.43g, 0.05mol), TEBA (0.45g, 0.002mol) and 100mL of water into a 250mL reaction flask, at room temperature The reaction was stirred for 12 hours, and 2.6 g of white solid (target compound I, 1ab) was obtained after filtration, with a yield of 98% (calculated as 8-acetamidoquinoline).
References:
CN111320579,2020,A Location in patent:Paragraph 0026-0031; 0130-0137
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99851-80-6
18 suppliers
$46.00/1g