![](/CAS/GIF/625-56-9.gif)
Chloromethyl acetate synthesis
- Product Name:Chloromethyl acetate
- CAS Number:625-56-9
- Molecular formula:C3H5ClO2
- Molecular Weight:108.52
![Acetyl chloride](/CAS/GIF/75-36-5.gif)
75-36-5
563 suppliers
$17.92/100G
![Chloromethyl acetate](/CAS/GIF/625-56-9.gif)
625-56-9
88 suppliers
$50.00/1g
Yield:625-56-9 94%
Reaction Conditions:
with formaldehyd;zinc(II) chloride at 0 - 90; for 19 h;Inert atmosphere;
Steps:
49.1 Synthesis of chloromethyl acetate
Acetyl chloride (5g,0.O6mol)was addeddropwisetoamixtureofparaform-aldhyde (8.5 g, 0.06 mol) and anhydrous zinc chloride(0.175 g, 0.02 mol) at 0° C. under Argon. The reaction mixture was warmed to room temperature and stirred for 1hour, then heated to 90° C. for 18 hours. The solid was filtered off washed with dichloromethane, and the filtrate was concentrated under vacuum at 37° C. to provide thedesired product (6.6 g, 94% yield). The product was useddirectly (without purification) in to next step and stored with activated molecular sieves (4° A).
References:
Alkermes Pharma Ireland Limited;Blumberg, Laura Cook;Remenar, Julius F.;Almarsson, Orn;Zeidan, Tarek A. US9102618, 2015, B2 Location in patent:Page/Page column 426
![Methyl acetate](/CAS/GIF/79-20-9.gif)
79-20-9
533 suppliers
$14.00/100g
![Chloromethyl acetate](/CAS/GIF/625-56-9.gif)
625-56-9
88 suppliers
$50.00/1g
![Formaldehyde](/CAS/GIF/50-00-0.gif)
50-00-0
846 suppliers
$10.00/25g
![Acetyl chloride](/CAS/GIF/75-36-5.gif)
75-36-5
563 suppliers
$17.92/100G
![BIS(CHLOROMETHYL)ETHER](/CAS/20180808/GIF/542-88-1.gif)
542-88-1
2 suppliers
inquiry
![Chloromethyl acetate](/CAS/GIF/625-56-9.gif)
625-56-9
88 suppliers
$50.00/1g
![1,3,5-trioxane](/CAS/GIF/110-88-3.gif)
110-88-3
228 suppliers
$10.00/25g
![Acetic acid](/CAS/GIF/64-19-7.gif)
64-19-7
1536 suppliers
$10.00/25ML
![Chloromethyl acetate](/CAS/GIF/625-56-9.gif)
625-56-9
88 suppliers
$50.00/1g