![](/CAS/GIF/28319-77-9.gif)
Choline glycerophosphate synthesis
- Product Name:Choline glycerophosphate
- CAS Number:28319-77-9
- Molecular formula:C8H20NO6P
- Molecular Weight:257.22
![Calcium phosphorylcholine chloride](/CAS/GIF/4826-71-5.gif)
4826-71-5
164 suppliers
$8.00/5g
![(R)-(+)-Glycidol](/CAS/GIF/57044-25-4.gif)
57044-25-4
250 suppliers
$6.00/1g
![Choline glycerophosphate](/CAS/GIF/28319-77-9.gif)
28319-77-9
453 suppliers
$5.00/250mg
Yield:28319-77-9 289 g
Reaction Conditions:
Stage #1: phosphorylcholine chloride, calcium saltwith sodium carbonate in water at 20; for 1 h;
Stage #2: (R)-oxiranemethanolReflux;Reagent/catalyst;Concentration;
Steps:
1 Example one
Add in the reactorPhosphorylcholine calcium salt (usually tetrahydrate) 330g and 300ml water,Stir until dissolvedA sodium carbonate solution with a concentration of 50% made of anhydrous sodium carbonate (106 g) and water was dropped and dropped at a rate of 10 ml/min. After the dropwise addition, the mixture was stirred at room temperature for 1 hour. The salt solution was passed according to the solubility of sodium chloride. Precipitation of sodium chloride in the reaction systemfilter. The filtrate was passed through a sulfonic acid ion column and eluted with water several times to HPLC without product.The solvent was distilled under reduced pressure and concentrated to a volume of 300 ml.66 g of (R)-chiral glycidol was added, and the reaction was stirred at reflux for 2-6 hours. HPLC showed no raw material, and the water was evaporated under reduced pressure and recrystallized from methanol to obtain 289 g of product. (HPLC > 99.7%)
References:
CN104628766,2017,B Location in patent:Paragraph 0044; 0045; 0046; 0047; 0048; 0049; 0050-0059
![(R)-(-)-3-Chloro-1,2-propanediol](/CAS/GIF/57090-45-6.gif)
57090-45-6
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$9.00/25g
![phosphorylcholine](/CAS/GIF/107-73-3.gif)
107-73-3
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inquiry
![Choline glycerophosphate](/CAS/GIF/28319-77-9.gif)
28319-77-9
453 suppliers
$5.00/250mg
![phosphorylcholine](/CAS/GIF/107-73-3.gif)
107-73-3
143 suppliers
inquiry
![(R)-(+)-Glycidol](/CAS/GIF/57044-25-4.gif)
57044-25-4
250 suppliers
$6.00/1g
![Choline glycerophosphate](/CAS/GIF/28319-77-9.gif)
28319-77-9
453 suppliers
$5.00/250mg